| 8/30/2018 | Clark Atlanta (3-7) | 30 | at | Mississippi College | 31 | SIAC | ||
| 9/8/2018 | Southwest Baptist (0-10) | 9 | at | Mississippi College | 34 | GLV | ||
| 9/15/2018 | Mississippi College | at | North Greenville (4-6,3-4) | CCD | ||||
| 9/22/2018 | West Florida (6-5,4-4) | 34 | at | Mississippi College | 21 | |||
| 9/29/2018 | Valdosta State (14-0,8-0) | 63 | at | Mississippi College | 42 | |||
| 10/6/2018 | Mississippi College | 24 | at | Florida Tech (8-4,5-3) | 31 | |||
| 10/13/2018 | Mississippi College | 17 | at | North Alabama (7-3) | 34 | at Ind1AA | ||
| 10/20/2018 | Mississippi College | 37 | at | Shorter (0-11,0-8) | 24 | |||
| 10/27/2018 | West Georgia (10-2,7-1) | 36 | at | Mississippi College | 21 | |||
| 11/3/2018 | West Alabama (8-4,5-3) | 24 | at | Mississippi College | 3 | |||
| 11/10/2018 | Mississippi College | 21 | at | Delta State (2-8,2-6) | 28 |
| vs Mississippi College | vs Other Opponents | Mississippi College compared to OOs | |
| Record: | 7-3 | 55-57 | |
| Points Scored: | 31.30 | 26.54 | -4.76 |
| Points Allowed: | 25.10 | 28.19 | -3.09 |
| Margin: | 6.20 | -1.65 | -7.85 |
| Total Points: | 56.40 | 54.73 | 1.67 |