| 9/1/2016 | Wofford (10-4) | 21 | at | Tennessee Tech | 7 | SoCon | ||
| 9/10/2016 | Tennessee Tech | 41 | at | Austin Peay (0-11,0-8) | 7 | |||
| 9/17/2016 | Tennessee Tech | 27 | at | Mercer (6-5) | 34 | at SoCon | ||
| 9/24/2016 | Tennessee Tech | 23 | at | Tennessee-Martin (7-5,6-2) | 44 | |||
| 10/1/2016 | Eastern Kentucky (3-8,2-6) | 30 | at | Tennessee Tech | 33 | OT | ||
| 10/8/2016 | Tennessee Tech | 21 | at | Jacksonville State (10-2,7-0) | 40 | |||
| 10/15/2016 | Eastern Illinois (6-5,4-4) | 30 | at | Tennessee Tech | 24 | |||
| 10/22/2016 | SE Missouri State (3-8,3-5) | 20 | at | Tennessee Tech | 21 | |||
| 11/5/2016 | Tennessee Tech | 0 | at | Tennessee (9-4) | 55 | at SEC | ||
| 11/12/2016 | Tennessee Tech | 44 | at | Tennessee State (7-4,4-3) | 16 | |||
| 11/19/2016 | Murray State (4-7,4-4) | 19 | at | Tennessee Tech | 55 |
| vs Tennessee Tech | vs Other Opponents | Tennessee Tech compared to OOs | |
| Record: | 6-5 | 59-58 | |
| Points Scored: | 28.73 | 28.20 | -0.53 |
| Points Allowed: | 26.91 | 28.14 | -1.23 |
| Margin: | 1.82 | 0.06 | -1.76 |
| Total Points: | 55.64 | 56.34 | -0.70 |