| 9/3/2016 | Ark Pine Bluff (1-10) | 0 | at | Tennessee State | 44 | SWAC | ||
| 9/10/2016 | Jackson State (3-8) | 26 | vs | Tennessee State | 40 | Memphis TN | SWAC | |
| 9/17/2016 | Tennessee State | 31 | at | Bethune-Cookman (4-6) | 24 | at MEAC | ||
| 10/1/2016 | Tennessee-Martin (7-5,6-2) | 30 | at | Tennessee State | 34 | |||
| 10/8/2016 | Tennessee State | 34 | at | Eastern Illinois (6-5,4-4) | 35 | |||
| 10/15/2016 | Eastern Kentucky (3-8,2-6) | 28 | at | Tennessee State | 35 | |||
| 10/22/2016 | Tennessee State | 17 | at | Vanderbilt (6-7) | 35 | at SEC | ||
| 10/29/2016 | Tennessee State | 31 | at | Murray State (4-7,4-4) | 38 | |||
| 11/5/2016 | Tennessee State | 41 | at | Austin Peay (0-11,0-8) | 40 | |||
| 11/12/2016 | Tennessee Tech (5-6,5-3) | 44 | at | Tennessee State | 16 | |||
| 11/19/2016 | Tennessee State | 32 | at | SE Missouri State (3-8,3-5) | 31 |
| vs Tennessee State | vs Other Opponents | Tennessee State compared to OOs | |
| Record: | 4-7 | 38-74 | |
| Points Scored: | 30.09 | 23.32 | -6.77 |
| Points Allowed: | 32.27 | 30.46 | 1.81 |
| Margin: | -2.18 | -7.14 | -4.96 |
| Total Points: | 62.36 | 53.78 | 8.58 |