| 9/3/2016 | SE Missouri State | 17 | at | Memphis (8-5) | 35 | at AAC | ||
| 9/10/2016 | SE Missouri State | 22 | at | Southern Illinois (4-7) | 30 | at MVC | ||
| 9/17/2016 | Indiana State (4-7) | 27 | at | SE Missouri State | 24 | MVC | ||
| 9/24/2016 | SE Missouri State | 17 | at | Murray State (4-7,4-4) | 16 | |||
| 10/1/2016 | Eastern Illinois (6-5,4-4) | 14 | at | SE Missouri State | 21 | |||
| 10/8/2016 | SE Missouri State | 16 | at | Eastern Kentucky (3-8,2-6) | 31 | |||
| 10/22/2016 | SE Missouri State | 20 | at | Tennessee Tech (5-6,5-3) | 21 | |||
| 10/29/2016 | Austin Peay (0-11,0-8) | 21 | at | SE Missouri State | 41 | |||
| 11/5/2016 | Jacksonville State (10-2,7-0) | 17 | at | SE Missouri State | 10 | |||
| 11/12/2016 | SE Missouri State | 10 | at | Tennessee-Martin (7-5,6-2) | 24 | |||
| 11/19/2016 | Tennessee State (7-4,4-3) | 32 | at | SE Missouri State | 31 |
| vs SE Missouri State | vs Other Opponents | SE Missouri State compared to OOs | |
| Record: | 8-3 | 50-64 | |
| Points Scored: | 24.36 | 29.71 | 5.35 |
| Points Allowed: | 20.82 | 31.11 | -10.29 |
| Margin: | 3.54 | -1.40 | -4.94 |
| Total Points: | 45.18 | 60.82 | -15.64 |