| 9/3/2016 | Alabama A&M (4-7) | 0 | at | Middle Tenn State | 55 | SWAC (1AA) | ||
| 9/10/2016 | Middle Tenn State | 24 | at | Vanderbilt (6-7) | 47 | at SEC | ||
| 9/17/2016 | Middle Tenn State | 41 | at | Bowling Green (4-8) | 21 | at MAC | ||
| 9/24/2016 | Louisiana Tech (9-5,6-3) | 34 | at | Middle Tenn State | 38 | |||
| 10/1/2016 | Middle Tenn State | 30 | at | North Texas (5-8,3-5) | 13 | |||
| 10/15/2016 | Western Kentucky (11-3,8-1) | 44 | at | Middle Tenn State | 43 | 2OT | ||
| 10/22/2016 | Middle Tenn State | 51 | at | Missouri (4-8) | 45 | at SEC | ||
| 10/29/2016 | Middle Tenn State | 42 | at | Florida Intl (4-8,4-4) | 35 | |||
| 11/5/2016 | Texas-San Antonio (6-7,5-3) | 45 | at | Middle Tenn State | 25 | |||
| 11/12/2016 | Middle Tenn State | 17 | at | Marshall (3-9,2-6) | 42 | |||
| 11/19/2016 | Middle Tenn State | 38 | at | UNC-Charlotte (4-8,3-5) | 31 | |||
| 11/26/2016 | Florida Atlantic (3-9,2-6) | 56 | at | Middle Tenn State | 77 | |||
| 12/24/2016 | Hawaii (7-7) | 52 | vs | Middle Tenn State | 35 | Hawai'I Bowl (Honolulu HI) | MW |
| vs Middle Tenn State | vs Other Opponents | Middle Tenn State compared to OOs | |
| Record: | 5-8 | 65-86 | |
| Points Scored: | 35.77 | 28.80 | -6.97 |
| Points Allowed: | 39.69 | 32.56 | 7.13 |
| Margin: | -3.92 | -3.76 | 0.16 |
| Total Points: | 75.46 | 61.36 | 14.10 |