| 9/2/2016 | Mississippi Valley State (1-10) | 14 | at | Eastern Michigan | 61 | SWAC (1AA) | ||
| 9/10/2016 | Eastern Michigan | 21 | at | Missouri (4-8) | 61 | at SEC | ||
| 9/17/2016 | Eastern Michigan | 37 | at | UNC-Charlotte (4-8) | 19 | at CUSA | ||
| 9/23/2016 | Wyoming (8-6) | 24 | at | Eastern Michigan | 27 | MW | ||
| 10/1/2016 | Eastern Michigan | 28 | at | Bowling Green (4-8,3-5) | 25 | |||
| 10/8/2016 | Toledo (9-4,6-2) | 35 | at | Eastern Michigan | 20 | |||
| 10/15/2016 | Eastern Michigan | 27 | at | Ohio (8-6,6-3) | 20 | |||
| 10/22/2016 | Eastern Michigan | 31 | at | Western Michigan (13-1,9-0) | 45 | |||
| 10/29/2016 | Miami-Ohio (6-7,6-2) | 28 | at | Eastern Michigan | 15 | |||
| 11/8/2016 | Eastern Michigan | 48 | at | Ball State (4-8,1-7) | 41 | |||
| 11/16/2016 | Northern Illinois (5-7,5-3) | 31 | at | Eastern Michigan | 24 | OT | ||
| 11/22/2016 | Central Michigan (6-7,3-5) | 21 | at | Eastern Michigan | 26 | |||
| 12/23/2016 | Eastern Michigan | 20 | vs | Old Dominion (10-3) | 24 | Popeyes Bahama Bowl (Nassau) | vs CUSA |
| vs Eastern Michigan | vs Other Opponents | Eastern Michigan compared to OOs | |
| Record: | 6-7 | 76-76 | |
| Points Scored: | 29.85 | 29.44 | -0.41 |
| Points Allowed: | 29.62 | 29.99 | -0.37 |
| Margin: | 0.23 | -0.55 | -0.78 |
| Total Points: | 59.47 | 59.43 | 0.04 |