| 9/2/2016 | Toledo | 31 | at | Arkansas State (8-5) | 10 | at SBC | ||
| 9/10/2016 | Maine (6-5) | 3 | at | Toledo | 45 | CAAF (1AA) | ||
| 9/17/2016 | Fresno State (1-11) | 17 | at | Toledo | 52 | MW | ||
| 9/30/2016 | Toledo | 53 | at | BYU (9-4) | 55 | at Ind | ||
| 10/8/2016 | Toledo | 35 | at | Eastern Michigan (7-6,4-4) | 20 | |||
| 10/15/2016 | Bowling Green (4-8,3-5) | 35 | at | Toledo | 42 | |||
| 10/22/2016 | Central Michigan (6-7,3-5) | 17 | at | Toledo | 31 | |||
| 10/27/2016 | Ohio (8-6,6-3) | 31 | at | Toledo | 26 | |||
| 11/2/2016 | Toledo | 48 | at | Akron (5-7,3-5) | 17 | |||
| 11/9/2016 | Toledo | 31 | vs | Northern Illinois (5-7,5-3) | 24 | Chicago IL | ||
| 11/16/2016 | Ball State (4-8,1-7) | 19 | at | Toledo | 37 | |||
| 11/25/2016 | Toledo | 35 | at | Western Michigan (13-1,9-0) | 55 | |||
| 12/17/2016 | Appalachian State (10-3) | 31 | vs | Toledo | 28 | Camellia Bowl (Montgomery AL) | SBC |
| vs Toledo | vs Other Opponents | Toledo compared to OOs | |
| Record: | 4-9 | 82-69 | |
| Points Scored: | 25.69 | 28.05 | 2.36 |
| Points Allowed: | 38.00 | 25.79 | 12.21 |
| Margin: | -12.31 | 2.26 | 14.57 |
| Total Points: | 63.69 | 53.84 | 9.85 |