| 9/1/2012 | Tulsa | 23 | at | Iowa State | 38 | | | vs CUSA |
| South Dakota State | 17 | at | Kansas | 31 | | | vs MVC (1AA) |
| Missouri State | 9 | at | Kansas State | 51 | | | vs MVC (1AA) |
| Savannah State | 0 | at | Oklahoma State | 84 | | | vs MEAC (1AA) |
| Wyoming | 17 | at | Texas | 37 | | | vs MW |
| Northwestern State | 6 | at | Texas Tech | 44 | | | vs SLC (1AA) |
| Oklahoma | 24 | at | UTEP | 7 | | | @ CUSA |
| Marshall | 34 | at | West Virginia | 69 | | | vs CUSA |
| 9/2/2012 | SMU | 24 | at | Baylor | 59 | | | vs CUSA |
| 9/8/2012 | Oklahoma State | 38 | at | Arizona | 59 | | | @ P12 |
| Iowa State | 9 | at | Iowa | 6 | | | @ B10 |
| Rice | 25 | at | Kansas | 24 | | | vs CUSA |
| Miami-Florida | 13 | at | Kansas State | 52 | | | vs ACC |
| Florida A&M | 13 | at | Oklahoma | 69 | | | vs MEAC (1AA) |
| Grambling | 0 | at | TCU | 56 | | | vs SWAC (1AA) |
| New Mexico | 0 | at | Texas | 45 | | | vs MW |
| Texas Tech | 58 | at | Texas State | 10 | | | @ WAC |
| 9/15/2012 | Sam Houston | 23 | at | Baylor | 48 | | | vs SLC (1AA) |
| Western Illinois | 3 | at | Iowa State | 37 | | | vs MVC (1AA) |
| West Virginia | 42 | vs | James Madison | 12 | | Landover MD | @ CAAF (1AA) |
| TCU | 20 | at | Kansas | 6 | | | |
| North Texas | 21 | at | Kansas State | 35 | | | vs SBC |
| Texas | 66 | at | Mississippi | 31 | | | @ SEC |
| UL Lafayette | 24 | at | Oklahoma State | 65 | | | vs SBC |
| New Mexico | 14 | at | Texas Tech | 49 | | | vs MW |
| 9/21/2012 | Baylor | 47 | at | UL Monroe | 42 | | | @ SBC |
| 9/22/2012 | Kansas | 23 | at | Northern Illinois | 30 | | | @ MAC |
| Kansas State | 24 | at | Oklahoma | 19 | | | |
| Virginia | 7 | at | TCU | 27 | | | vs ACC |
| Maryland | 21 | at | West Virginia | 31 | | | vs ACC |
| 9/29/2012 | Texas Tech | 24 | at | Iowa State | 13 | | | |
| Texas | 41 | at | Oklahoma State | 36 | | | |
| TCU | 24 | at | SMU | 16 | | | @ CUSA |
| Baylor | 63 | at | West Virginia | 70 | | | |
| 10/6/2012 | Kansas | 16 | at | Kansas State | 56 | | | |
| Iowa State | 37 | at | TCU | 23 | | | |
| West Virginia | 48 | at | Texas | 45 | | | |
| Oklahoma | 41 | at | Texas Tech | 20 | | | |
| 10/13/2012 | TCU | 49 | at | Baylor | 21 | | | |
| Kansas State | 27 | at | Iowa State | 21 | | | |
| Oklahoma State | 20 | at | Kansas | 14 | | | |
| Oklahoma | 63 | vs | Texas | 21 | | Dallas TX | |
| West Virginia | 14 | at | Texas Tech | 49 | | | |
| 10/20/2012 | Kansas | 7 | at | Oklahoma | 52 | | | |
| Iowa State | 10 | at | Oklahoma State | 31 | | | |
| Texas Tech | 56 | at | TCU | 53 | 2OT | | |
| Baylor | 50 | at | Texas | 56 | | | |
| Kansas State | 55 | at | West Virginia | 14 | | | |
| 10/27/2012 | Baylor | 21 | at | Iowa State | 35 | | | |
| Texas | 21 | at | Kansas | 17 | | | |
| Texas Tech | 24 | at | Kansas State | 55 | | | |
| Notre Dame | 30 | at | Oklahoma | 13 | | | vs ND |
| TCU | 14 | at | Oklahoma State | 36 | | | |
| 11/3/2012 | Kansas | 14 | at | Baylor | 41 | | | |
| Oklahoma | 35 | at | Iowa State | 20 | | | |
| Oklahoma State | 30 | at | Kansas State | 44 | | | |
| Texas | 31 | at | Texas Tech | 22 | | | |
| TCU | 39 | at | West Virginia | 38 | 2OT | | |
| 11/10/2012 | Baylor | 34 | at | Oklahoma | 42 | | | |
| West Virginia | 34 | at | Oklahoma State | 55 | | | |
| Kansas State | 23 | at | TCU | 10 | | | |
| Iowa State | 7 | at | Texas | 33 | | | |
| Kansas | 34 | at | Texas Tech | 41 | 2OT | | |
| 11/17/2012 | Kansas State | 24 | at | Baylor | 52 | | | |
| Iowa State | 51 | at | Kansas | 23 | | | |
| Texas Tech | 21 | at | Oklahoma State | 59 | | | |
| Oklahoma | 50 | at | West Virginia | 49 | | | |
| 11/22/2012 | TCU | 20 | at | Texas | 13 | | | |
| 11/23/2012 | West Virginia | 31 | at | Iowa State | 24 | | | |
| 11/24/2012 | Oklahoma State | 48 | at | Oklahoma | 51 | OT | | |
| Baylor | 52 | vs | Texas Tech | 45 | OT | Arlington TX | |
| 12/1/2012 | Oklahoma State | 34 | at | Baylor | 41 | | | |
| Texas | 24 | at | Kansas State | 42 | | | |
| Oklahoma | 24 | at | TCU | 17 | | | |
| Kansas | 10 | at | West Virginia | 59 | | | |
| 12/27/2012 | Baylor | 49 | vs | UCLA | 26 | | Bridgeport Education Holiday Bowl | @ P12 |
| 12/28/2012 | Minnesota | 31 | vs | Texas Tech | 34 | | Meineke Car Care Bowl of Texas | vs B10 |
| 12/29/2012 | TCU | 16 | vs | Michigan State | 17 | | Buffalo Wild Wings Bowl | @ B10 |
| Texas | 31 | vs | Oregon State | 27 | | Valero Alama Bowl | @ P12 |
| West Virginia | 14 | vs | Syracuse | 38 | | New Era Pinstripe Bowl | @ BigE |
| 12/31/2012 | Iowa State | 17 | vs | Tulsa | 31 | | AutoZone Libserty Bowl | @ CUSA |
| 1/1/2013 | Purdue | 14 | vs | Oklahoma State | 58 | | Heart of Dallas Bowl | vs B10 |
| 1/3/2013 | Oregon | 34 | vs | Kansas State | 17 | | Tostitos Fiesta Bowl | vs P12 |
| 1/4/2013 | Texas A&M | 41 | vs | Oklahoma | 13 | | AT&T Cotton Bowl | vs SEC |