| 9/2/2012 | SMU | 24 | at | Baylor (8-5) | 59 | at B12 | ||
| 9/8/2012 | Stephen F. Austin (5-6) | 0 | at | SMU | 52 | SLC (1AA) | ||
| 9/15/2012 | Texas A&M (11-2) | 48 | at | SMU | 3 | SEC | ||
| 9/29/2012 | TCU (7-6) | 24 | at | SMU | 16 | B12 | ||
| 10/6/2012 | SMU | 17 | at | UTEP (3-9,2-6) | 0 | |||
| 10/13/2012 | SMU | 26 | at | Tulane (2-10,2-6) | 27 | |||
| 10/18/2012 | Houston (5-7,4-4) | 42 | at | SMU | 72 | |||
| 10/27/2012 | Memphis (4-8,4-4) | 13 | at | SMU | 44 | |||
| 11/3/2012 | SMU | 17 | at | UCF (10-4,7-2) | 42 | |||
| 11/10/2012 | Southern Miss (0-12,0-8) | 6 | at | SMU | 34 | |||
| 11/17/2012 | SMU | 14 | at | Rice (7-6,4-4) | 36 | |||
| 11/24/2012 | Tulsa (11-3,8-1) | 27 | at | SMU | 35 | |||
| 12/24/2012 | Fresno State (9-4) | 10 | vs | SMU | 43 | Sheraton Hawaii Bowl | MW |
| vs SMU | vs Other Opponents | SMU compared to OOs | |
| Record: | 6-7 | 76-75 | |
| Points Scored: | 25.69 | 32.34 | 6.65 |
| Points Allowed: | 30.54 | 29.40 | 1.14 |
| Margin: | -4.85 | 2.94 | 7.79 |
| Total Points: | 56.23 | 61.74 | -5.51 |