| 9/1/2012 | Missouri State | 9 | at | Kansas State (11-2) | 51 | at B12 | ||
| 9/8/2012 | Missouri State | 7 | at | Louisville (11-2) | 35 | at BigE | ||
| 9/15/2012 | Murray State (5-6) | 28 | at | Missouri State | 23 | OVC | ||
| 9/22/2012 | Southern Illinois (6-5,5-3) | 14 | at | Missouri State | 6 | |||
| 9/29/2012 | Missouri State | 7 | at | South Dakota State (9-4,6-3) | 17 | |||
| 10/6/2012 | Missouri State | 17 | at | Indiana State (7-4,5-3) | 31 | |||
| 10/13/2012 | South Dakota (1-10,0-8) | 24 | at | Missouri State | 27 | |||
| 10/20/2012 | Missouri State | 24 | at | Illinois State (9-4,5-3) | 17 | |||
| 10/27/2012 | Western Illinois (3-8,1-7) | 3 | at | Missouri State | 42 | |||
| 11/3/2012 | North Dakota State (14-1,8-1) | 21 | at | Missouri State | 17 | |||
| 11/17/2012 | Missouri State | 13 | at | Northern Iowa (5-6,4-4) | 38 |
| vs Missouri State | vs Other Opponents | Missouri State compared to OOs | |
| Record: | 8-3 | 73-49 | |
| Points Scored: | 25.36 | 27.72 | 2.36 |
| Points Allowed: | 17.45 | 23.34 | -5.89 |
| Margin: | 7.91 | 4.38 | -3.53 |
| Total Points: | 42.81 | 51.06 | -8.25 |