| 8/31/2012 | Boise State (11-2) | 13 | at | Michigan State | 17 | MW | ||
| 9/8/2012 | Michigan State | 41 | at | Central Michigan (7-6) | 7 | at MAC | ||
| 9/15/2012 | Notre Dame (12-1) | 20 | at | Michigan State | 3 | ND | ||
| 9/22/2012 | Eastern Michigan (2-10) | 7 | at | Michigan State | 23 | MAC | ||
| 9/29/2012 | Ohio State (12-0,8-0) | 17 | at | Michigan State | 16 | |||
| 10/6/2012 | Michigan State | 31 | at | Indiana (4-8,2-6) | 27 | |||
| 10/13/2012 | Iowa (4-8,2-6) | 19 | at | Michigan State | 16 | 2OT | ||
| 10/20/2012 | Michigan State | 10 | at | Michigan (8-5,6-2) | 12 | |||
| 10/27/2012 | Michigan State | 16 | at | Wisconsin (8-6,5-4) | 13 | OT | ||
| 11/3/2012 | Nebraska (10-4,7-2) | 28 | at | Michigan State | 24 | |||
| 11/17/2012 | Northwestern (10-3,5-3) | 23 | at | Michigan State | 20 | |||
| 11/24/2012 | Michigan State | 26 | at | Minnesota (6-7,2-6) | 10 | |||
| 12/29/2012 | TCU (7-6) | 16 | vs | Michigan State | 17 | Buffalo Wild Wings Bowl | B12 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 6-7 | 95-59 | |
| Points Scored: | 16.31 | 29.55 | 13.24 |
| Points Allowed: | 20.00 | 24.52 | -4.52 |
| Margin: | -3.69 | 5.03 | 8.72 |
| Total Points: | 36.31 | 54.07 | -17.76 |