| 9/1/2012 | Iowa | 18 | vs | Northern Illinois (12-2) | 17 | Chicago IL | vs MAC | |
| 9/8/2012 | Iowa State (6-7) | 9 | at | Iowa | 6 | B12 | ||
| 9/15/2012 | Northern Iowa (5-6) | 16 | at | Iowa | 27 | MVC (1AA) | ||
| 9/22/2012 | Central Michigan (7-6) | 32 | at | Iowa | 31 | MAC | ||
| 9/29/2012 | Minnesota (6-7,2-6) | 13 | at | Iowa | 31 | |||
| 10/13/2012 | Iowa | 19 | at | Michigan State (7-6,3-5) | 16 | 2OT | ||
| 10/20/2012 | Penn State (8-4,6-2) | 38 | at | Iowa | 14 | |||
| 10/27/2012 | Iowa | 17 | at | Northwestern (10-3,5-3) | 28 | |||
| 11/3/2012 | Iowa | 21 | at | Indiana (4-8,2-6) | 24 | |||
| 11/10/2012 | Purdue (6-7,3-5) | 27 | at | Iowa | 24 | |||
| 11/17/2012 | Iowa | 17 | at | Michigan (8-5,6-2) | 42 | |||
| 11/23/2012 | Nebraska (10-4,7-2) | 13 | at | Iowa | 7 |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 8-4 | 81-61 | |
| Points Scored: | 22.92 | 29.70 | 6.78 |
| Points Allowed: | 19.33 | 24.94 | -5.61 |
| Margin: | 3.59 | 4.76 | 1.17 |
| Total Points: | 42.25 | 54.64 | -12.39 |