| 9/1/2012 | Northwestern (10-3) | 42 | at | Syracuse | 41 | B10 | ||
| 9/8/2012 | Southern California (7-6) | 42 | vs | Syracuse | 29 | East Rutherford NJ | P12 | |
| 9/15/2012 | Stony Brook (10-3) | 17 | at | Syracuse | 28 | BigS (1AA) | ||
| 9/22/2012 | Syracuse | 10 | at | Minnesota (6-7) | 17 | at B10 | ||
| 10/5/2012 | Pittsburgh (6-7,3-4) | 13 | at | Syracuse | 14 | |||
| 10/13/2012 | Syracuse | 15 | at | Rutgers (9-4,5-2) | 23 | |||
| 10/19/2012 | Connecticut (5-7,2-5) | 10 | at | Syracuse | 40 | |||
| 10/27/2012 | Syracuse | 37 | at | South Florida (3-9,1-6) | 36 | |||
| 11/3/2012 | Syracuse | 24 | at | Cincinnati (10-3,5-2) | 35 | |||
| 11/10/2012 | Louisville (11-2,5-2) | 26 | at | Syracuse | 45 | |||
| 11/17/2012 | Syracuse | 31 | at | Missouri (5-7) | 27 | at SEC | ||
| 11/23/2012 | Syracuse | 38 | at | Temple (4-7,2-5) | 20 | |||
| 12/29/2012 | West Virginia (7-6) | 14 | vs | Syracuse | 38 | New Era Pinstripe Bowl | B12 |
| vs Syracuse | vs Other Opponents | Syracuse compared to OOs | |
| Record: | 5-8 | 88-63 | |
| Points Scored: | 24.77 | 28.13 | 3.36 |
| Points Allowed: | 30.00 | 23.15 | 6.85 |
| Margin: | -5.23 | 4.98 | 10.21 |
| Total Points: | 54.77 | 51.28 | 3.49 |