| 8/30/2012 | UCLA (9-5) | 49 | at | Rice | 24 | P12 | ||
| 9/8/2012 | Rice | 25 | at | Kansas (1-11) | 24 | at B12 | ||
| 9/15/2012 | Rice | 37 | at | Louisiana Tech (9-3) | 56 | at WAC | ||
| 9/22/2012 | Marshall (5-7,4-4) | 54 | at | Rice | 51 | 2OT | ||
| 9/29/2012 | Houston (5-7,4-4) | 35 | vs | Rice | 14 | Houston TX | ||
| 10/6/2012 | Rice | 10 | at | Memphis (4-8,4-4) | 14 | |||
| 10/13/2012 | Texas-San Antonio (8-4) | 14 | at | Rice | 34 | WAC | ||
| 10/20/2012 | Rice | 24 | at | Tulsa (11-3,8-1) | 28 | |||
| 10/27/2012 | Southern Miss (0-12,0-8) | 17 | at | Rice | 44 | |||
| 11/3/2012 | Rice | 49 | at | Tulane (2-10,2-6) | 47 | |||
| 11/17/2012 | SMU (7-6,5-3) | 14 | at | Rice | 36 | |||
| 11/24/2012 | Rice | 33 | at | UTEP (3-9,2-6) | 24 | |||
| 12/29/2012 | Rice | 33 | vs | Air Force (6-7) | 14 | Bell Helicoptor Armed Forces Bowl | vs MW |
| vs Rice | vs Other Opponents | Rice compared to OOs | |
| Record: | 6-7 | 64-85 | |
| Points Scored: | 30.00 | 29.95 | -0.05 |
| Points Allowed: | 31.85 | 32.47 | -0.62 |
| Margin: | -1.85 | -2.52 | -0.67 |
| Total Points: | 61.85 | 62.42 | -0.57 |