| 9/4/2010 | Western Kentucky | 10 | @ | Nebraska | 49 | ||||
| 9/11/2010 | Western Kentucky | 28 | @ | Kentucky | 63 | ||||
| 9/18/2010 | Indiana | 38 | @ | Western Kentucky | 21 | ||||
| 9/25/2010 | Western Kentucky | 12 | @ | South Florida | 24 | ||||
| 10/9/2010 | Western Kentucky | 21 | @ | Florida Intl | 28 | SBC | |||
| 10/16/2010 | UL Monroe | 35 | @ | Western Kentucky | 30 | SBC | |||
| 10/23/2010 | Western Kentucky | 54 | @ | UL Lafayette | 21 | SBC | |||
| 10/30/2010 | North Texas | 33 | @ | Western Kentucky | 6 | SBC | |||
| 11/6/2010 | Florida Atlantic | 17 | @ | Western Kentucky | 16 | SBC | |||
| 11/13/2010 | Western Kentucky | 36 | @ | Arkansas State | 35 | OT | SBC | ||
| 11/20/2010 | Middle Tenn State | 27 | @ | Western Kentucky | 26 | SBC | |||
| 11/27/2010 | Western Kentucky | 14 | @ | Troy | 28 | SBC |