| 9/4/2010 | Texas | 34 | @ | Rice | 17 | ||||
| 9/11/2010 | Wyoming | 7 | @ | Texas | 34 | ||||
| 9/18/2010 | Texas | 24 | @ | Texas Tech | 14 | B12 | |||
| 9/25/2010 | UCLA | 34 | @ | Texas | 12 | ||||
| 10/2/2010 | Oklahoma | 28 | vs | Texas | 20 | B12 | Dallas TX | ||
| 10/16/2010 | Texas | 20 | @ | Nebraska | 13 | B12 | |||
| 10/23/2010 | Iowa State | 28 | @ | Texas | 21 | B12 | |||
| 10/30/2010 | Baylor | 30 | @ | Texas | 22 | B12 | |||
| 11/6/2010 | Texas | 14 | @ | Kansas State | 39 | B12 | |||
| 11/13/2010 | Oklahoma State | 33 | @ | Texas | 16 | B12 | |||
| 11/20/2010 | Florida Atlantic | 17 | @ | Texas | 51 | ||||
| 11/25/2010 | Texas A&M | 24 | @ | Texas | 17 | B12 |