| 9/4/2010 | Syracuse | 29 | @ | Akron | 3 | ||||
| 9/11/2010 | Syracuse | 20 | @ | Washington | 41 | ||||
| 9/18/2010 | Maine 1AA | 14 | @ | Syracuse | 38 | ||||
| 9/25/2010 | Colgate 1AA | 7 | @ | Syracuse | 42 | ||||
| 10/9/2010 | Syracuse | 13 | @ | South Florida | 9 | BigE | |||
| 10/16/2010 | Pittsburgh | 45 | @ | Syracuse | 14 | BigE | |||
| 10/23/2010 | Syracuse | 19 | @ | West Virginia | 14 | BigE | |||
| 10/30/2010 | Syracuse | 31 | @ | Cincinnati | 7 | BigE | |||
| 11/6/2010 | Louisville | 28 | @ | Syracuse | 20 | BigE | |||
| 11/13/2010 | Syracuse | 13 | @ | Rutgers | 10 | BigE | |||
| 11/20/2010 | Connecticut | 23 | @ | Syracuse | 6 | BigE | |||
| 11/27/2010 | Boston College | 16 | @ | Syracuse | 7 | ||||
| 12/30/2010 | Kansas State | 34 | vs | Syracuse | 36 | New York - Pinstripe Bowl |