| 9/4/2010 | South Dakota 1AA | 7 | @ | UCF | 38 | ||||
| 9/11/2010 | North Carolina State | 28 | @ | UCF | 21 | ||||
| 9/18/2010 | UCF | 24 | @ | Buffalo | 10 | ||||
| 9/25/2010 | UCF | 13 | @ | Kansas State | 17 | ||||
| 10/6/2010 | UAB | 7 | @ | UCF | 42 | CUSA | |||
| 10/13/2010 | UCF | 35 | @ | Marshall | 14 | CUSA | |||
| 10/23/2010 | Rice | 14 | @ | UCF | 41 | CUSA | |||
| 10/30/2010 | East Carolina | 35 | @ | UCF | 49 | CUSA | |||
| 11/5/2010 | UCF | 40 | @ | Houston | 33 | CUSA | |||
| 11/13/2010 | Southern Miss | 31 | @ | UCF | 21 | CUSA | |||
| 11/20/2010 | UCF | 61 | @ | Tulane | 14 | CUSA | |||
| 11/27/2010 | UCF | 37 | @ | Memphis | 17 | CUSA | |||
| 12/4/2010 | SMU | 7 | @ | UCF | 17 | CUSA | CUSA Championship | ||
| 12/31/2010 | UCF | 10 | vs | Georgia | 6 | Memphis - Liberty Bowl |