| 9/2/2010 | Marshall | 7 | @ | Ohio State | 45 | ||||
| 9/11/2010 | Miami-Florida | 24 | @ | Ohio State | 36 | ||||
| 9/18/2010 | Ohio | 7 | @ | Ohio State | 43 | ||||
| 9/25/2010 | Eastern Michigan | 20 | @ | Ohio State | 73 | ||||
| 10/2/2010 | Ohio State | 24 | @ | Illinois | 13 | B10 | |||
| 10/9/2010 | Indiana | 10 | @ | Ohio State | 38 | B10 | |||
| 10/16/2010 | Ohio State | 18 | @ | Wisconsin | 31 | B10 | |||
| 10/23/2010 | Purdue | 0 | @ | Ohio State | 49 | B10 | |||
| 10/30/2010 | Ohio State | 52 | @ | Minnesota | 10 | B10 | |||
| 11/13/2010 | Penn State | 14 | @ | Ohio State | 38 | B10 | |||
| 11/20/2010 | Ohio State | 20 | @ | Iowa | 17 | B10 | |||
| 11/27/2010 | Michigan | 7 | @ | Ohio State | 37 | B10 | |||
| 1/4/2011 | Ohio State | 31 | vs | Arkansas | 26 | New Orleans - Sugar Bowl |