| 9/4/2010 | Northwestern | 23 | @ | Vanderbilt | 21 | ||||
| 9/11/2010 | Illinois State 1AA | 3 | @ | Northwestern | 37 | ||||
| 9/18/2010 | Northwestern | 30 | @ | Rice | 13 | ||||
| 9/25/2010 | Central Michigan | 25 | @ | Northwestern | 30 | ||||
| 10/2/2010 | Northwestern | 29 | @ | Minnesota | 28 | B10 | |||
| 10/9/2010 | Purdue | 20 | @ | Northwestern | 17 | B10 | |||
| 10/23/2010 | Michigan State | 35 | @ | Northwestern | 27 | B10 | |||
| 10/30/2010 | Northwestern | 20 | @ | Indiana | 17 | B10 | |||
| 11/6/2010 | Northwestern | 21 | @ | Penn State | 35 | B10 | |||
| 11/13/2010 | Iowa | 17 | @ | Northwestern | 21 | B10 | |||
| 11/20/2010 | Illinois | 48 | @ | Northwestern | 27 | B10 | |||
| 11/27/2010 | Northwestern | 23 | @ | Wisconsin | 70 | B10 | |||
| 1/1/2011 | Northwestern | 38 | vs | Texas Tech | 45 | Dallas - TicketCity Bowl |