| 9/4/2010 | Western Michigan | 14 | @ | Michigan State | 38 | ||||
| 9/11/2010 | Michigan State | 30 | vs | Florida Atlantic | 17 | Detroit MI | |||
| 9/18/2010 | Notre Dame | 31 | @ | Michigan State | 34 | OT | |||
| 9/25/2010 | Northern Colorado 1AA | 7 | @ | Michigan State | 45 | ||||
| 10/2/2010 | Wisconsin | 24 | @ | Michigan State | 34 | B10 | |||
| 10/9/2010 | Michigan State | 34 | @ | Michigan | 17 | B10 | |||
| 10/16/2010 | Illinois | 6 | @ | Michigan State | 26 | B10 | |||
| 10/23/2010 | Michigan State | 35 | @ | Northwestern | 27 | B10 | |||
| 10/30/2010 | Michigan State | 6 | @ | Iowa | 37 | B10 | |||
| 11/6/2010 | Minnesota | 8 | @ | Michigan State | 31 | B10 | |||
| 11/20/2010 | Purdue | 31 | @ | Michigan State | 35 | B10 | |||
| 11/27/2010 | Michigan State | 28 | @ | Penn State | 22 | B10 | |||
| 1/1/2011 | Alabama | 49 | vs | Michigan State | 7 | Orlando - Capital One Bowl |