| 9/4/2010 | Connecticut | 10 | @ | Michigan | 30 | ||||
| 9/11/2010 | Michigan | 28 | @ | Notre Dame | 24 | ||||
| 9/18/2010 | Massachusetts 1AA | 37 | @ | Michigan | 42 | ||||
| 9/25/2010 | Bowling Green | 21 | @ | Michigan | 65 | ||||
| 10/2/2010 | Michigan | 42 | @ | Indiana | 35 | B10 | |||
| 10/9/2010 | Michigan State | 34 | @ | Michigan | 17 | B10 | |||
| 10/16/2010 | Iowa | 38 | @ | Michigan | 28 | B10 | |||
| 10/30/2010 | Michigan | 31 | @ | Penn State | 41 | B10 | |||
| 11/6/2010 | Illinois | 65 | @ | Michigan | 67 | 3 OT | B10 | ||
| 11/13/2010 | Michigan | 27 | @ | Purdue | 16 | B10 | |||
| 11/20/2010 | Wisconsin | 48 | @ | Michigan | 28 | B10 | |||
| 11/27/2010 | Michigan | 7 | @ | Ohio State | 37 | B10 | |||
| 1/1/2011 | Mississippi State | 52 | vs | Michigan | 14 | Jacksonville - Gator Bowl |