| 9/4/2021 | West Florida (9-2) | 42 | at | McNeese State | 36 | GSC (D2) | ||
| 9/11/2021 | McNeese State | 7 | at | LSU (6-7) | 34 | at SEC | ||
| 9/18/2021 | McNeese State | 31 | at | Southern (4-7) | 24 | at SWAC | ||
| 9/25/2021 | McNeese State | 0 | at | Incarnate Word (10-3,7-1) | 31 | |||
| 10/2/2021 | Southeastern Louisiana (9-4,6-2) | 38 | at | McNeese State | 35 | |||
| 10/16/2021 | McNeese State | 35 | at | Northwestern State (3-8,3-5) | 17 | |||
| 10/23/2021 | Incarnate Word (10-3,7-1) | 20 | at | McNeese State | 28 | |||
| 10/30/2021 | McNeese State | 20 | at | Southeastern Louisiana (9-4,6-2) | 23 | |||
| 11/6/2021 | Nicholls State (6-5,5-3) | 24 | at | McNeese State | 14 | |||
| 11/13/2021 | McNeese State | 44 | at | Houston Baptist (0-11,0-8) | 3 | |||
| 11/20/2021 | Northwestern State (3-8,3-5) | 24 | at | McNeese State | 20 |
| vs McNeese State | vs Other Opponents | McNeese State compared to OOs | |
| Record: | 7-4 | 58-56 | |
| Points Scored: | 25.45 | 35.46 | 10.01 |
| Points Allowed: | 24.55 | 32.99 | -8.44 |
| Margin: | 0.90 | 2.47 | 1.57 |
| Total Points: | 50.00 | 68.45 | -18.45 |