| 9/4/2021 | Texas-Permian Basin (5-6) | 24 | at | Southwest Baptist | 16 | LSC | ||
| 9/11/2021 | Southwest Baptist | 14 | at | West Florida (9-2) | 63 | at GSC | ||
| 9/18/2021 | Findlay (8-4) | 62 | at | Southwest Baptist | 41 | GMAC | ||
| 9/25/2021 | Southwest Baptist | 28 | at | Lake Erie (5-6) | 20 | at GMAC | ||
| 10/2/2021 | Indianapolis (7-4,5-1) | 77 | at | Southwest Baptist | 10 | |||
| 10/9/2021 | Southwest Baptist | 55 | at | William Jewell (0-11,0-6) | 10 | |||
| 10/16/2021 | Truman State (9-3,4-2) | 21 | at | Southwest Baptist | 27 | |||
| 10/23/2021 | Southwest Baptist | 24 | at | Lindenwood (9-3) | 48 | at MAIAA | ||
| 10/30/2021 | McKendree (4-7,3-3) | 45 | at | Southwest Baptist | 42 | |||
| 11/6/2021 | Southwest Baptist | 47 | at | Quincy (4-7,2-4) | 31 | |||
| 11/13/2021 | Missouri S&T (6-5,4-2) | 42 | at | Southwest Baptist | 41 |
| vs Southwest Baptist | vs Other Opponents | Southwest Baptist compared to OOs | |
| Record: | 7-4 | 59-54 | |
| Points Scored: | 40.27 | 30.46 | -9.81 |
| Points Allowed: | 31.36 | 28.73 | 2.63 |
| Margin: | 8.91 | 1.73 | -7.18 |
| Total Points: | 71.63 | 59.19 | 12.44 |