| 9/4/2010 | Hastings Broncos 33 @ Briar Cliff 0 | † |
| 9/11/2010 | Briar Cliff 37 @ Waldorf Warriors 7 | |
| 9/18/2010 | Briar Cliff 12 @ Morningside Mustangs 58 | † |
| 9/25/2010 | Northwestern IA Red Raiders 59 @ Briar Cliff 38 | † |
| 10/2/2010 | Briar Cliff 17 @ Dordt Defenders 7 | † |
| 10/9/2010 | Sioux Falls Cougars 66 @ Briar Cliff 21 | † |
| 10/16/2010 | Briar Cliff 26 @ Concordia NE Bulldogs 30 | † |
| 10/23/2010 | Briar Cliff 27 @ Nebraska Wesleyan Prairie Wolves 34 | † |
| 10/30/2010 | Midland Lutheran Warriors 31 @ Briar Cliff 10 | † |
| 11/6/2010 | Briar Cliff 14 @ Dakota Wesleyan Tigers 49 | † |
| 11/13/2010 | Doane Tigers 42 @ Briar Cliff 14 | † |