| 9/4/2010 | Anna Maria 21 @ Worcester State Lancers 49 | |
| 9/11/2010 | Maine Maritime Mariners 47 @ Anna Maria 0 | |
| 9/18/2010 | Anna Maria 0 @ Malone Pioneers 69 | |
| 9/25/2010 | Anna Maria 32 @ Becker Hawks 43 | † |
| 10/2/2010 | SUNY-Maritime Privateers 43 @ Anna Maria 20 | † |
| 10/9/2010 | Husson Eagles 53 @ Anna Maria 38 | † |
| 10/16/2010 | Castleton State Spartans 49 @ Anna Maria 35 | † |
| 10/23/2010 | Norwich Cadets 81 @ Anna Maria 7 | † |
| 10/30/2010 | Anna Maria 6 @ Gallaudet Bison 33 | † |
| 11/6/2010 | Anna Maria 18 @ Mount Ida Mustangs 69 | † |