| 9/2/2010 | Malone Pioneers 21 @ Tiffin 31 | |
| 9/11/2010 | Wayne State MI Warriors 63 @ Tiffin 14 | † |
| 9/18/2010 | Findlay Oilers 10 @ Tiffin 7 | † |
| 9/25/2010 | Tiffin 28 @ Ferris State Bulldogs 52 | † |
| 10/2/2010 | Grand Valley State Lakers 71 @ Tiffin 10 | † |
| 10/9/2010 | Tiffin 0 @ Ashland Eagles 49 | † |
| 10/16/2010 | Tiffin 27 @ Northwood Timberwolves 51 | † |
| 10/23/2010 | Ohio Dominican Panthers 41 @ Tiffin 21 | † |
| 10/30/2010 | Northern Michigan Wildcats 43 @ Tiffin 14 | † |
| 11/6/2010 | Tiffin 27 @ Lake Erie Storm 31 | † |
| 11/13/2010 | Tiffin 24 @ Hillsdale Chargers 31 | † |