| 9/4/2010 | MidAmerica Nazarene 42 @ Avila Eagles 7 | † |
| 9/11/2010 | Baker Wildcats 16 @ MidAmerica Nazarene 24 | † |
| 9/18/2010 | MidAmerica Nazarene 46 @ Culver-Stockton Wildcats 13 | † |
| 9/25/2010 | Lindenwood Lions 20 @ MidAmerica Nazarene 26 | † |
| 10/2/2010 | MidAmerica Nazarene 23 @ Benedictine KS Ravens 7 | † |
| 10/9/2010 | Graceland Yellow Jackets 22 @ MidAmerica Nazarene 54 | † |
| 10/16/2010 | MidAmerica Nazarene 29 @ William Jewell Cardinals 7 | † |
| 10/23/2010 | Evangel Crusaders 10 @ MidAmerica Nazarene 45 | † |
| 10/30/2010 | MidAmerica Nazarene 56 @ Central Methodist Eagles 28 | † |
| 11/6/2010 | Missouri Valley Vikings 7 @ MidAmerica Nazarene 37 | † |
| 11/20/2010 | Georgetown KY Tigers 24 @ MidAmerica Nazarene 27 | |
| 11/27/2010 | Morningside Mustangs 10 @ MidAmerica Nazarene 34 | |
| 12/4/2010 | MidAmerica Nazarene 0 @ Sioux Falls Cougars 38 |