| 9/4/2010 | William Jewell Cardinals 0 @ Benedictine KS 21 | † |
| 9/11/2010 | Benedictine KS 38 @ Evangel Crusaders 19 | † |
| 9/18/2010 | Central Methodist Eagles 14 @ Benedictine KS 38 | † |
| 9/25/2010 | Benedictine KS 21 @ Missouri Valley Vikings 34 | † |
| 10/2/2010 | MidAmerica Nazarene Pioneers 23 @ Benedictine KS 7 | † |
| 10/9/2010 | Benedictine KS 47 @ Avila Eagles 7 | † |
| 10/16/2010 | Baker Wildcats 20 @ Benedictine KS 14 | † |
| 10/23/2010 | Benedictine KS 45 @ Culver-Stockton Wildcats 17 | † |
| 10/30/2010 | Lindenwood Lions 40 @ Benedictine KS 24 | † |
| 11/6/2010 | Benedictine KS 28 @ Peru State Bobcats 0 | |
| 11/13/2010 | Benedictine KS 24 @ Graceland Yellow Jackets 6 | † |