| 9/4/2010 | Central Methodist Eagles 40 @ Culver-Stockton 0 | † |
| 9/11/2010 | Culver-Stockton 0 @ Missouri Valley Vikings 70 | † |
| 9/18/2010 | MidAmerica Nazarene Pioneers 46 @ Culver-Stockton 13 | † |
| 9/25/2010 | Culver-Stockton 7 @ Avila Eagles 21 | † |
| 10/2/2010 | Baker Wildcats 63 @ Culver-Stockton 10 | † |
| 10/9/2010 | Peru State Bobcats 24 @ Culver-Stockton 14 | |
| 10/16/2010 | Culver-Stockton 19 @ Lindenwood Lions 90 | † |
| 10/23/2010 | Benedictine KS Ravens 45 @ Culver-Stockton 17 | † |
| 10/30/2010 | Culver-Stockton 38 @ Graceland Yellow Jackets 33 | † |
| 11/6/2010 | William Jewell Cardinals 21 @ Culver-Stockton 13 | † |
| 11/13/2010 | Culver-Stockton 31 @ Evangel Crusaders 45 | † |