| 8/28/2010 | Midland Lutheran 38 @ Dakota State Trojans 7 | |
| 9/11/2010 | Sioux Falls Cougars 37 @ Midland Lutheran 7 | † |
| 9/18/2010 | Midland Lutheran 7 @ Concordia NE Bulldogs 3 | † |
| 9/25/2010 | Morningside Mustangs 36 @ Midland Lutheran 7 | † |
| 10/2/2010 | Midland Lutheran 21 @ Dakota Wesleyan Tigers 19 | † |
| 10/9/2010 | Midland Lutheran 35 @ Hastings Broncos 23 | † |
| 10/16/2010 | Doane Tigers 10 @ Midland Lutheran 48 | † |
| 10/23/2010 | Dordt Defenders 0 @ Midland Lutheran 42 | † |
| 10/30/2010 | Midland Lutheran 31 @ Briar Cliff Chargers 10 | † |
| 11/6/2010 | Midland Lutheran 14 @ Nebraska Wesleyan Prairie Wolves 6 | † |
| 11/13/2010 | Northwestern IA Red Raiders 24 @ Midland Lutheran 6 | † |