| 8/28/2010 | Midland Lutheran Warriors 38 @ Dakota State 7 | |
| 9/11/2010 | Dakota State 7 @ Wisconsin-Whitewater Warhawks 70 | |
| 9/18/2010 | Dakota State 7 @ Dickinson State Blue Hawks 31 | † |
| 9/25/2010 | South Dakota Tech Jackrabbits 41 @ Dakota State 14 | † |
| 10/2/2010 | Dakota State 9 @ Black Hills State Yellow Jackets 14 | † |
| 10/9/2010 | Minot State Beavers 35 @ Dakota State 19 | † |
| 10/16/2010 | Dakota State 10 @ Valley City State Vikings 54 | † |
| 10/23/2010 | Jamestown Jimmies 58 @ Dakota State 48 | † |
| 10/30/2010 | Dakota State 14 @ Mayville State Comets 21 | † |