| 9/4/2010 | Sioux Falls Cougars 41 @ Northwestern IA 24 | † |
| 9/11/2010 | Northwestern IA 24 @ Hastings Broncos 10 | † |
| 9/18/2010 | Nebraska Wesleyan Prairie Wolves 14 @ Northwestern IA 30 | † |
| 9/25/2010 | Northwestern IA 59 @ Briar Cliff Chargers 38 | † |
| 10/2/2010 | Morningside Mustangs 20 @ Northwestern IA 17 | † |
| 10/16/2010 | Northwestern IA 48 @ Dordt Defenders 3 | † |
| 10/23/2010 | Northwestern IA 31 @ Doane Tigers 23 | † |
| 10/30/2010 | Dakota Wesleyan Tigers 10 @ Northwestern IA 16 | † |
| 11/6/2010 | Concordia NE Bulldogs 6 @ Northwestern IA 26 | † |
| 11/13/2010 | Northwestern IA 24 @ Midland Lutheran Warriors 6 | † |