| 9/4/2010 | Hastings 33 @ Briar Cliff Chargers 0 | † |
| 9/11/2010 | Northwestern IA Red Raiders 24 @ Hastings 10 | † |
| 9/18/2010 | Hastings 35 @ Dordt Defenders 0 | † |
| 9/25/2010 | Sioux Falls Cougars 34 @ Hastings 10 | † |
| 10/2/2010 | Hastings 23 @ Concordia NE Bulldogs 6 | † |
| 10/9/2010 | Midland Lutheran Warriors 35 @ Hastings 23 | † |
| 10/16/2010 | Hastings 21 @ Dakota Wesleyan Tigers 34 | † |
| 10/30/2010 | Hastings 7 @ Morningside Mustangs 43 | † |
| 11/6/2010 | Doane Tigers 21 @ Hastings 43 | † |
| 11/13/2010 | Nebraska Wesleyan Prairie Wolves 14 @ Hastings 17 | † |