| 9/4/2010 | Doane 7 @ Morningside Mustangs 40 | † |
| 9/11/2010 | Dordt Defenders 10 @ Doane 36 | † |
| 9/18/2010 | Doane 13 @ Sioux Falls Cougars 66 | † |
| 9/25/2010 | Dakota Wesleyan Tigers 37 @ Doane 3 | † |
| 10/9/2010 | Concordia NE Bulldogs 14 @ Doane 42 | † |
| 10/16/2010 | Doane 10 @ Midland Lutheran Warriors 48 | † |
| 10/23/2010 | Northwestern IA Red Raiders 31 @ Doane 23 | † |
| 10/30/2010 | Nebraska Wesleyan Prairie Wolves 34 @ Doane 14 | † |
| 11/6/2010 | Doane 21 @ Hastings Broncos 43 | † |
| 11/13/2010 | Doane 42 @ Briar Cliff Chargers 14 | † |