| 9/4/2010 | Nebraska Wesleyan 0 @ Concordia NE Bulldogs 3 | † |
| 9/11/2010 | Morningside Mustangs 23 @ Nebraska Wesleyan 12 | † |
| 9/18/2010 | Nebraska Wesleyan 14 @ Northwestern IA Red Raiders 30 | † |
| 9/25/2010 | Dordt Defenders 0 @ Nebraska Wesleyan 21 | † |
| 10/2/2010 | Nebraska Wesleyan 0 @ Sioux Falls Cougars 44 | † |
| 10/9/2010 | Dakota Wesleyan Tigers 20 @ Nebraska Wesleyan 27 | † |
| 10/23/2010 | Briar Cliff Chargers 27 @ Nebraska Wesleyan 34 | † |
| 10/30/2010 | Nebraska Wesleyan 34 @ Doane Tigers 14 | † |
| 11/6/2010 | Midland Lutheran Warriors 14 @ Nebraska Wesleyan 6 | † |
| 11/13/2010 | Nebraska Wesleyan 14 @ Hastings Broncos 17 | † |