| 9/4/2010 | Peru State Bobcats 54 @ Jamestown 56 | |
| 9/11/2010 | Jamestown 24 @ Wisconsin-Stout Blue Devils 27 | |
| 9/18/2010 | Black Hills State Yellow Jackets 28 @ Jamestown 25 | † |
| 9/25/2010 | Jamestown 16 @ Dickinson State Blue Hawks 26 | † |
| 10/2/2010 | Minot State Beavers 19 @ Jamestown 14 | † |
| 10/9/2010 | Jamestown 7 @ South Dakota Tech Jackrabbits 31 | † |
| 10/16/2010 | Mayville State Comets 7 @ Jamestown 44 | † |
| 10/23/2010 | Jamestown 58 @ Dakota State Trojans 48 | † |
| 10/30/2010 | Valley City State Vikings 13 @ Jamestown 19 | † |