| 9/11/2010 | Mount Union 45 @ Wisconsin-Oshkosh Titans 28 | |
| 9/18/2010 | Mount Union 51 @ John Carroll Blue Streaks 7 | † |
| 9/25/2010 | Mount Union 51 @ Wilmington Quakers 0 | † |
| 10/2/2010 | Ohio Northern Polar Bears 0 @ Mount Union 27 | † |
| 10/9/2010 | Mount Union 28 @ Marietta Pioneers 14 | † |
| 10/16/2010 | Heidelberg Fighting Student Princes 7 @ Mount Union 45 | † |
| 10/23/2010 | Capital Crusaders 0 @ Mount Union 38 | † |
| 10/30/2010 | Mount Union 28 @ Otterbein Cardinals 10 | † |
| 11/6/2010 | Mount Union 41 @ Baldwin-Wallace Yellow Jackets 13 | † |
| 11/13/2010 | Muskingum Muskies 0 @ Mount Union 52 | † |
| 11/20/2010 | St Lawrence Saints 0 @ Mount Union 49 (D3 Playoffs Round 1) | |
| 11/27/2010 | Delaware Valley Aggies 3 @ Mount Union 31 | |
| 12/4/2010 | Alfred Saxons 7 @ Mount Union 37 | |
| 12/11/2010 | Bethel MN Royals 14 @ Mount Union 34 | |
| 12/18/2010 | Wisconsin-Whitewater Warhawks 31 vs Mount Union 21 (Salem VA - Amos Alonzo Stagg Bowl (D3 Championship)) |