| 9/4/2010 | North Central 41 @ Cornell IA Rams 7 | |
| 9/18/2010 | North Central 52 @ Olivet Comets 9 | |
| 9/25/2010 | Wisconsin-Eau Claire Blugolds 6 @ North Central 20 | |
| 10/2/2010 | Carthage Red Men 8 @ North Central 43 | † |
| 10/9/2010 | North Central 34 @ Augustana IL Vikings 14 | † |
| 10/16/2010 | Millikin Big Blue 7 @ North Central 38 | † |
| 10/23/2010 | Illinois Wesleyan Titans 7 @ North Central 30 | † |
| 10/30/2010 | North Central 47 @ Elmhurst Bluejays 13 | † |
| 11/6/2010 | North Central 28 @ Wheaton Thunder 6 | † |
| 11/13/2010 | North Park Vikings 7 @ North Central 61 | † |
| 11/20/2010 | St Norbert Green Knights 7 @ North Central 57 (D3 Playoffs Round 1) | |
| 11/27/2010 | Ohio Northern Polar Bears 9 @ North Central 28 | |
| 12/4/2010 | Wisconsin-Whitewater Warhawks 20 @ North Central 10 |