| 9/3/2010 | King's Monarchs 7 @ Springfield 31 | |
| 9/11/2010 | Springfield 51 @ Husson Eagles 0 | |
| 9/18/2010 | Springfield 44 @ Wilkes Colonels 7 | |
| 9/25/2010 | Alfred Saxons 35 @ Springfield 28 | † |
| 10/2/2010 | Merchant Marine Mariners 0 @ Springfield 64 | |
| 10/16/2010 | Utica Pioneers 16 @ Springfield 20 | † |
| 10/23/2010 | Springfield 14 @ Ithaca Bombers 23 | † |
| 10/30/2010 | Hartwick Hawks 20 @ Springfield 39 | † |
| 11/6/2010 | Springfield 55 @ St John Fisher Cardinals 49 | † |
| 11/13/2010 | Union NY Dutchmen 15 @ Springfield 26 | |
| 11/20/2010 | Mount Ida Mustangs 17 @ Springfield 26 (ECAC North Atlantic Bowl) |