| 9/11/2010 | Michigan Tech 42 @ Lake Erie Storm 13 | † |
| 9/18/2010 | Wayne State MI Warriors 7 @ Michigan Tech 24 | † |
| 9/25/2010 | Michigan Tech 24 @ Indianapolis Greyhounds 10 | † |
| 10/2/2010 | Ohio Dominican Panthers 6 @ Michigan Tech 45 | † |
| 10/9/2010 | Michigan Tech 31 @ Saginaw Valley State Cardinals 43 | † |
| 10/16/2010 | Michigan Tech 17 @ Hillsdale Chargers 24 | † |
| 10/23/2010 | Northwood Timberwolves 30 @ Michigan Tech 62 | † |
| 10/30/2010 | Grand Valley State Lakers 17 @ Michigan Tech 20 | † |
| 11/6/2010 | Michigan Tech 28 @ Ferris State Bulldogs 16 | † |
| 11/13/2010 | Northern Michigan Wildcats 0 @ Michigan Tech 12 | † |