| 9/11/2010 | Northwood Timberwolves 28 @ Ohio Dominican 12 | † |
| 9/18/2010 | Ferris State Bulldogs 34 @ Ohio Dominican 28 | † |
| 9/25/2010 | Ohio Dominican 7 @ Wayne State MI Warriors 17 | † |
| 10/2/2010 | Ohio Dominican 6 @ Michigan Tech Huskies 45 | † |
| 10/9/2010 | Hillsdale Chargers 35 @ Ohio Dominican 10 | † |
| 10/16/2010 | Findlay Oilers 10 @ Ohio Dominican 20 | † |
| 10/23/2010 | Ohio Dominican 41 @ Tiffin Dragons 21 | † |
| 10/30/2010 | Ohio Dominican 15 @ Lake Erie Storm 30 | † |
| 11/6/2010 | Ashland Eagles 44 @ Ohio Dominican 15 | † |
| 11/13/2010 | Ohio Dominican 17 @ Indianapolis Greyhounds 31 | † |