| 9/4/2010 | Bloomsburg Huskies 14 @ Ashland 24 | |
| 9/11/2010 | Ashland 12 @ Indianapolis Greyhounds 17 | † |
| 9/18/2010 | Hillsdale Chargers 27 @ Ashland 17 | † |
| 9/25/2010 | Ashland 19 @ Northern Michigan Wildcats 23 | † |
| 10/2/2010 | Northwood Timberwolves 17 @ Ashland 37 | † |
| 10/9/2010 | Tiffin Dragons 0 @ Ashland 49 | † |
| 10/16/2010 | Ashland 40 @ Wayne State MI Warriors 35 | † |
| 10/23/2010 | Saginaw Valley State Cardinals 24 @ Ashland 30 | † |
| 10/30/2010 | Ashland 56 @ Findlay Oilers 7 | † |
| 11/6/2010 | Ashland 44 @ Ohio Dominican Panthers 15 | † |
| 11/13/2010 | Lake Erie Storm 17 @ Ashland 87 | † |