| 9/1/2005 | Drake | 17 | @ | Northern Iowa | 52 | ||||
| 9/10/2005 | Drake | 19 | @ | Illinois St | 56 | ||||
| 9/17/2005 | Drake | 37 | @ | UW-Platteville | 14 | ||||
| 9/24/2005 | Austin Peay | 0 | @ | Drake | 54 | Pio | |||
| 10/1/2005 | Drake | 58 | @ | Davidson | 17 | Pio | |||
| 10/8/2005 | Dayton | 25 | @ | Drake | 17 | Pio | |||
| 10/22/2005 | Drake | 26 | @ | San Diego | 31 | Pio | |||
| 10/29/2005 | Butler | 10 | @ | Drake | 56 | Pio | |||
| 11/5/2005 | Drake | 49 | @ | Valparaiso | 24 | Pio | |||
| 11/12/2005 | Waldorf | 0 | @ | Drake | 43 |