| 9/3/2005 | Ball State | 0 | @ | #25 Iowa | 56 | ||||
| 9/10/2005 | #25 Iowa | 3 | @ | Iowa State | 23 | ||||
| 9/17/2005 | Northern Iowa | 21 | @ | #25 Iowa | 45 | ||||
| 9/24/2005 | #25 Iowa | 6 | @ | #4 Ohio State | 31 | B10 | |||
| 10/1/2005 | Illinois | 7 | @ | #25 Iowa | 35 | B10 | |||
| 10/8/2005 | #25 Iowa | 34 | @ | Purdue | 17 | B10 | |||
| 10/15/2005 | Indiana | 21 | @ | #25 Iowa | 38 | B10 | |||
| 10/22/2005 | #20 Michigan | 23 | @ | #25 Iowa | 20 | OT | B10 | ||
| 11/5/2005 | #25 Iowa | 27 | @ | Northwestern | 28 | B10 | |||
| 11/12/2005 | #25 Iowa | 20 | @ | #20 Wisconsin | 10 | B10 | |||
| 11/19/2005 | Minnesota | 28 | @ | #25 Iowa | 52 | B10 | |||
| 1/2/2006 | #25 Iowa | 24 | vs | #16 Florida | 31 | Outback |