| 9/3/2005 | #17 UCLA | 44 | @ | San Diego St | 21 | ||||
| 9/10/2005 | San Diego St | 29 | @ | Air Force | 41 | MW | |||
| 9/17/2005 | San Diego St | 6 | @ | #4 Ohio State | 27 | ||||
| 9/24/2005 | San Jose St | 21 | @ | San Diego St | 52 | ||||
| 10/1/2005 | BYU | 10 | @ | San Diego St | 31 | MW | |||
| 10/8/2005 | San Diego St | 10 | @ | UNLV | 13 | MW | |||
| 10/15/2005 | San Diego St | 28 | @ | Utah | 19 | MW | |||
| 10/22/2005 | New Mexico | 47 | @ | San Diego St | 24 | MW | |||
| 10/29/2005 | #14 TCU | 23 | @ | San Diego St | 20 | MW | |||
| 11/12/2005 | San Diego St | 30 | @ | Colorado St | 10 | MW | |||
| 11/19/2005 | Wyoming | 21 | @ | San Diego St | 34 | MW | |||
| 12/3/2005 | San Diego St | 38 | @ | Hawaii | 49 |