| 9/3/2005 | Western Michigan | 19 | @ | Virginia | 31 | ||||
| 9/10/2005 | Western Michigan | 23 | @ | Toledo | 56 | MAC | |||
| 9/17/2005 | Southern Illinois | 28 | @ | Western Michigan | 34 | ||||
| 9/24/2005 | Western Michigan | 19 | @ | Temple | 16 | ||||
| 10/1/2005 | Buffalo | 21 | @ | Western Michigan | 31 | MAC | |||
| 10/8/2005 | Ball State | 60 | @ | Western Michigan | 57 | 5 OT | MAC | ||
| 10/22/2005 | Western Michigan | 45 | @ | Bowling Green | 14 | MAC | |||
| 10/29/2005 | Kent St | 14 | @ | Western Michigan | 44 | MAC | |||
| 11/5/2005 | Western Michigan | 44 | @ | Eastern Michigan | 36 | MAC | |||
| 11/12/2005 | Central Michigan | 24 | @ | Western Michigan | 31 | MAC | |||
| 11/23/2005 | Western Michigan | 7 | @ | Northern Illinois | 42 | MAC |