| 9/3/2005 | Ohio | 14 | @ | Northwestern | 38 | ||||
| 9/9/2005 | Pittsburgh | 10 | @ | Ohio | 16 | OT | |||
| 9/17/2005 | Ohio | 0 | @ | #11 Virginia Tech | 45 | ||||
| 9/24/2005 | Kent St | 32 | @ | Ohio | 35 | MAC | |||
| 10/8/2005 | Ohio | 14 | @ | Bowling Green | 38 | MAC | |||
| 10/15/2005 | Ohio | 10 | @ | Central Michigan | 37 | MAC | |||
| 10/22/2005 | Ball State | 21 | @ | Ohio | 38 | MAC | |||
| 10/29/2005 | Ohio | 34 | @ | Buffalo | 20 | MAC | |||
| 11/4/2005 | Toledo | 30 | @ | Ohio | 21 | MAC | |||
| 11/15/2005 | Ohio | 3 | @ | Akron | 27 | MAC | |||
| 11/21/2005 | Miami-Ohio | 38 | @ | Ohio | 7 | MAC |