| 8/27/2022 | Missouri Baptist (4-7) | 12 | at | Lyon | 24 | MSFA | ||
| 9/3/2022 | Ottawa AZ (7-2,7-2) | 70 | at | Lyon | 0 | |||
| 9/10/2022 | Lyon | 14 | at | Wayland Baptist (2-8,2-7) | 37 | |||
| 9/24/2022 | Panhandle State (4-6,4-5) | 26 | at | Lyon | 19 | |||
| 10/1/2022 | Lyon | 3 | at | Langston (6-4,5-4) | 43 | |||
| 10/8/2022 | Lyon | 8 | at | Arizona Christian (8-3,7-2) | 60 | |||
| 10/15/2022 | Texas College (1-9,1-8) | 38 | at | Lyon | 34 | |||
| 10/22/2022 | Southwestern Assemblies of God (7-4,6-3) | 31 | at | Lyon | 6 | |||
| 11/5/2022 | Lyon | 3 | at | Louisiana College (7-4,6-3) | 50 | |||
| 11/12/2022 | Lyon | 21 | at | Texas Wesleyan (8-2,7-2) | 64 |
| vs Lyon | vs Other Opponents | Lyon compared to OOs | |
| Record: | 9-1 | 45-48 | |
| Points Scored: | 43.10 | 28.95 | -14.15 |
| Points Allowed: | 13.20 | 29.59 | -16.39 |
| Margin: | 29.90 | -0.64 | -30.54 |
| Total Points: | 56.30 | 58.54 | -2.24 |