| 8/27/2022 | Missouri Baptist | 12 | at | Lyon | 24 | | | MSFA |
| Friends | 31 | at | Panhandle State | 14 | | | KCAC |
| 9/3/2022 | Texas Wesleyan | 48 | at | Arizona Christian | 21 | | | |
| Texas College | 12 | at | Arkansas Baptist | 31 | | | @ None (Unk?) |
| Panhandle State | 13 | at | Langston | 48 | | | |
| Ottawa AZ | 70 | at | Lyon | 0 | | | |
| Louisiana College | 0 | at | Southwestern Assemblies of God | 27 | | | |
| Hardin-Simmons | 79 | at | Wayland Baptist | 14 | | | ASWC (D3) |
| 9/10/2022 | Arizona Christian | 52 | at | Fort Lewis | 12 | | | @ RMAC (D2) |
| Southwestern Assemblies of God | 12 | at | Ottawa AZ | 39 | | | |
| Louisiana College | 14 | at | Stetson | 45 | | | @ Pio (1AA) |
| Langston | 55 | at | Texas College | 24 | | | |
| Panhandle State | 0 | at | Texas Wesleyan | 52 | | | |
| Lyon | 14 | at | Wayland Baptist | 37 | | | |
| 9/17/2022 | Wayland Baptist | 24 | at | Langston | 56 | | | |
| Arizona Christian | 26 | at | Louisiana College | 40 | | | |
| Texas College | 6 | at | Panhandle State | 53 | | | |
| Ottawa AZ | 27 | at | Texas Wesleyan | 22 | | | |
| 9/24/2022 | Langston | 45 | at | Arkansas Baptist | 8 | | | @ None (Unk?) |
| Panhandle State | 26 | at | Lyon | 19 | | | |
| Louisiana College | 13 | at | Ottawa AZ | 45 | | | |
| Arizona Christian | 28 | at | Southwestern Assemblies of God | 20 | | | |
| Texas College | 31 | at | Wayland Baptist | 65 | | | |
| 10/1/2022 | Ottawa AZ | 38 | at | Arizona Christian | 40 | | | |
| Lyon | 3 | at | Langston | 43 | | | |
| Louisiana College | 16 | at | Panhandle State | 28 | | | |
| Arkansas Baptist | 20 | at | Southwestern Assemblies of God | 47 | | | None (Unk?) |
| Texas Wesleyan | 59 | at | Wayland Baptist | 16 | | | |
| 10/8/2022 | Lyon | 8 | at | Arizona Christian | 60 | | | |
| Arkansas Baptist | 14 | at | Louisiana College | 42 | | | None (Unk?) |
| Wayland Baptist | 10 | at | Panhandle State | 38 | | | |
| Texas College | 0 | at | Ottawa AZ | 56 | | | |
| Southwestern Assemblies of God | 0 | at | Texas Wesleyan | 35 | | | |
| 10/15/2022 | Wayland Baptist | 17 | at | Louisiana College | 37 | | | |
| Texas College | 38 | at | Lyon | 34 | | | |
| Panhandle State | 18 | at | Southwestern Assemblies of God | 41 | | | |
| Langston | 28 | at | Texas Wesleyan | 53 | | | |
| 10/22/2022 | Ottawa AZ | 38 | at | Langston | 44 | OT | | |
| Texas Wesleyan | 9 | at | Louisiana College | 33 | | | |
| Southwestern Assemblies of God | 31 | at | Lyon | 6 | | | |
| Arizona Christian | 81 | at | Texas College | 19 | | | |
| 10/29/2022 | Panhandle State | 0 | at | Arizona Christian | 41 | | | |
| Louisiana College | 39 | at | Langston | 14 | | | |
| Texas Wesleyan | 40 | at | Texas College | 12 | | | |
| Southwestern Assemblies of God | 30 | at | Wayland Baptist | 0 | | | |
| 11/5/2022 | Langston | 27 | at | Arizona Christian | 30 | | | |
| Lyon | 3 | at | Louisiana College | 50 | | | |
| Wayland Baptist | 14 | at | Ottawa AZ | 38 | | | |
| Texas College | 28 | at | Southwestern Assemblies of God | 47 | | | |
| North American U | 7 | at | Texas Wesleyan | 61 | | | None (Unk?) |
| 11/12/2022 | Ottawa AZ | 40 | at | Panhandle State | 6 | | | |
| Langston | 21 | at | Southwestern Assemblies of God | 39 | | | |
| Louisiana College | 56 | at | Texas College | 6 | | | |
| Lyon | 21 | at | Texas Wesleyan | 64 | | | |
| Arizona Christian | 41 | at | Wayland Baptist | 14 | | | |
| 11/18/2022 | Southwestern Assemblies of God | 16 | at | Olivet Nazarene | 21 | | NCCAA Victory Bowl - Waxahachee TX | @ MSFA |
| 11/19/2022 | Arizona Christian | 18 | at | Morningside | 35 | | NAIA Championship Round 1 | @ GPAC |